In 1982, Sinise's career began to take off when he directed and starred in Steppenwolf's production of True West. In 1983, he earned an Obie Award for his direction and a year later appeared with John Malkovich in the PBS' American Playhouse production of the play. In 1988, Gary directed Miles from Home, a movie starring Richard Gere, about two brothers' fight against the foreclosure of the family farm. It is considered a commentary on the issue that troubled many family farms in the 1980s. It was shot entirely on location in Iowa.
Sinise has also appeared in Forrest Gump, Of Mice and Men, Apollo 13, Reindeer Games, Mission to Mars, and The Stand. He has starred in two adaptations of John Steinbeck novels, Of Mice and Men, which he also directed, as well as the television broadcast version of The Grapes of Wrath. He also narrated the audio books for Travels with Charley and Of Mice and Men and is reportedly a great Steinbeck fan. Sinise once directed an episode of Thirtysomething, where his friend Terry Kinney had a recurring role.
In 2004, he began his first regular television series, in the crime drama CSI: New York, in which he plays Detective Mac Taylor. Sinise's musical prowess is demonstrated in CSI: NY season 2 episode 14, where, in the last moments of the episode, he plays the bass guitar in a jazz club with musicians Kimo and Carol Williams. Kimo Williams is a real life friend outside of television, and they belong to a band called the Lt. Dan Band, which frequently plays for the USO and other events.
He has appeared in three films with Tom Hanks: Forrest Gump, Apollo 13, and The Green Mile.
It is rumored that he will play Dr. McCoy in Star Trek, a film reimagining of Star Trek.
He is the host in the video for the Epcot ride Mission: SPACE, at Walt Disney World, Orlando, FL.
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